The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.Previously, we have shown that genetic or Cardigans pharmacological inhibition of ERAP1 on murine and human tumor cell lines perturbs the engagement of NK cel
Doron Kabaso1*, Maruša Lokar1*, Veronika Kralj-Iglic2, Peter Veranic3, Aleš Iglic11Laboratory of Biophysics, Faculty of Electrical Engineering, 2Laboratory of Clinical Biophysics, Faculty of Medicine, 3Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; *These two authors Tablet Mount
In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized.Based on docking results, multiple optimizations were made on the coumarin scaffold.Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed Day Bed obvious inhibitory effects on the E
An idealized model of an arterial wall is proposed as a two-layer system.Distinct mechanical response of each layer is taken into account considering two types of strain Tools and Templates energy functions in the hyperelasticity framework.The outer layer, considered as a fibre-reinforced composite, is modelled using the structural model of Holzapf